Contraceptive potential of the porcine zona pellucida vaccine in the African elephant (loxodonta africana)
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Cited by (34)
Effect of different adjuvant formulations on the antibody response of horses to porcine zona pellucida proteins
2022, Veterinary Immunology and ImmunopathologyCitation Excerpt :Immunocontraception is a potential tool to control wild horse populations in a cost-effective manner (Bartholow, 2007; de Seve and Griffin, 2013). Immunization with porcine zona pellucida (PZP) proteins has been used successfully to induce infertility in wild-roaming horses, deer, elephants and many other zoo animals and wildlife (Fayrer-Hosken et al., 1999; Kirkpatrick et al., 1992; Kirkpatrick et al., 2011). The infertility is thought to be due to anti-PZP antibodies that crossreact with zona pellucida proteins of the target species, and interfere with binding of sperm cells to the oocyte (Kirkpatrick et al., 2011).
Elephants
2018, Veterinary Reproduction & ObstetricsOvarian dysfunction associated with zona pellucida–based immunocontraceptive vaccines
2017, TheriogenologyCitation Excerpt :This hypothesis currently remains a commonly advanced argument [39]. Specific binding of anti-ZP antibodies within the developing ovarian follicle, primarily within the ZP, occasionally involving adjacent oolemma or granulosa cells, has been demonstrated in the rabbit [40], cat, dog, horse, and African elephant [41,42]. Similar findings have been demonstrated using immunofluorescence in both primates [43,44] and rabbits [45].
Fecal 20-oxo-pregnane concentrations in free-ranging African elephants (Loxodonta africana) treated with porcine zona pellucida vaccine
2012, TheriogenologyCitation Excerpt :Amongst wild populations, the information gleaned regarding estrous cycles has been inconclusive due to the common occurrence of pregnancy or lactation anestrus among females [26–28]. Monitoring luteal endocrine function via fecal hormone analysis has made it possible to examine the reproductive biology of wild and captive animals [1,18]. Fecal samples can be easily collected and noninvasive methods have already been developed and successfully tested to enable the measurement of progestagen metabolites in elephant feces [22,29].
Immunoglobulin to zona pellucida 3 mediates ovarian damage and infertility after contraceptive vaccination in mice
2010, Journal of AutoimmunityMHC haplotypes and response to immunocontraceptive vaccines in the brushtail possum
2009, Journal of Reproductive ImmunologyCitation Excerpt :However, trials on captured wild possums have revealed considerable individual variation in response to any given immunocontraceptive vaccine (Duckworth et al., 2007; Cui and Duckworth, 2005). Similarly, tests of immunocontraceptive vaccines in a wide range of species have shown a proportion of the immunised animals remain fertile (Magiafoglou et al., 2003; Miller et al., 1999, 1997; Kirkpatrick et al., 1996; Liu et al., 1989; Turner et al., 1996; Garrott et al., 1998; Fayrer-Hosken et al., 1999; Goldberg et al., 1981; Bradley et al., 1997). If a vaccine was applied to a wild population this variability could result in selection for individuals that remain fertile because of low or no response to the vaccine (Magiafoglou et al., 2003).