Theriogenology
Volume 76, Issue 8 , Pages 1496-1500 , November 2011

Probing the perils of dichotomous binning: How categorizing female dogs as spayed or intact can misinform our assumptions about the lifelong health consequences of ovariohysterectomy

  • D.J. Waters

      Affiliations

    • Department of Veterinary Clinical Sciences, Purdue University; West Lafayette, Indiana
    • Gerald P. Murphy Cancer Foundation, West Lafayette, Indiana
    • Corresponding Author InformationCorresponding author. Tel.: +1 765 775 1005; fax: +1 765 775 1006
    • ,
  • S.S. Kengeri

      Affiliations

    • Gerald P. Murphy Cancer Foundation, West Lafayette, Indiana
    • ,
  • A.H. Maras

      Affiliations

    • Gerald P. Murphy Cancer Foundation, West Lafayette, Indiana
    • ,
  • E.C. Chiang

      Affiliations

    • Gerald P. Murphy Cancer Foundation, West Lafayette, Indiana

Received 23 November 2010 ,Revised 15 June 2011 ,Accepted 16 June 2011.

References 

  1. Johnson W. People in Quandaries. Harper and Brothers; 1946;
  2. Waters DJ, Chiang EC. It's a U-shaped world: a Batesonian prescription for promoting public health. ETC. 2010;67:218–226
  3. Waters DJ, Waters LS. On the self-renewal of teachers. J Vet Med Educ. 2011;(in press)
  4. Cooley DM, Schlittler DL, Glickman LT, Hayek M, Waters DJ. Exceptional longevity in pet dogs is accompanied by cancer resistance and delayed onset of major diseases. J Gerontol A Biol Sci Med Sci. 2003;58:B1078–B1084
  5. Waters DJ, Wildasin K. Cancer clues from pet dogs. Sci Am. 2006;295:94–101
  6. Waters DJ, Kengeri SS, Clever B, Booth JA, Maras AH, Schlittler DL, et al. Exploring mechanisms of sex differences in longevity: lifetime ovary exposure and exceptional longevity in dogs. Aging Cell. 2009;8:752–755
  7. Root Kustritz MV. Determining the optimal age for gonadectomy of dogs and cats. J Am Vet Med Assoc. 2007;231:1665–1675
  8. Bronson RT. Variation in age at death of dogs of different sexes and breeds. Am J Vet Res. 1982;43:2057–2059
  9. Michell AR. Longevity of British breeds of dog and its relationships with sex, size, cardiovascular variables and disease. Vet Rec. 1999;145:625–629
  10. Moore GE, Burkman KD, Carter MN, Peterson MR. Causes of death or reasons for euthanasia in military working dogs: 927 cases (1993-1996). J Am Vet Med Assoc. 2001;219:209–214
  11. Thompson IM, Ankerst DP, Etzioni R, Wang T. It's time to abandon an upper limit of normal for prostate specific antigen: assessing the risk for prostate cancer. J Urol. 2008;180:1219–1222

PII: S0093-691X(11)00302-5

doi: 10.1016/j.theriogenology.2011.06.017

Theriogenology
Volume 76, Issue 8 , Pages 1496-1500 , November 2011

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