Theriogenology
Volume 74, Issue 8 , Pages 1450-1466 , November 2010

Expression of prostaglandin E2 receptor subtypes in the canine lower urinary tract varies according to the gonadal status and gender

  • S. Ponglowhapan

      Affiliations

    • Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330 Thailand
    • Department of Veterinary Clinical Sciences, The Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
    • ,
  • D.B. Church

      Affiliations

    • Department of Veterinary Clinical Sciences, The Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
    • ,
  • M. Khalid

      Affiliations

    • Department of Veterinary Clinical Sciences, The Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 (0)1707 666539

Received 21 January 2010 ,Revised 14 June 2010 ,Accepted 14 June 2010.

References 

  1. Wada M, DeLong CJ, Hong YH, Rieke CJ, Song I, Sidhu RS, et al. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem. 2007;282:22254–22266
  2. Mikhailidis DP, Jeremy JY, Dandona P. Urinary bladder prostanoids – their synthesis, function and possible role in the pathogenesis and treatment of disease. J Urol. 1987;137:577–582
  3. Klarskov P, Gerstenberg T, Ramirez D, Christensen P, Hald T. Prostaglandin type E activity dominates in urinary tract smooth muscle in vitro. J Urol. 1983;129:1071–1074
  4. Coleman RA, Kennedy I, Humphrey PPA, Bunce K, Lumley P. Prostanoids and their receptors: Membranes and Receptors. In: Comprehensive Medicinal Chemistry. Oxford: Pergamon Press; 1990;p. 643–714
  5. Ushikubi F, Hirata M, Narumiya S. Molecular biology of prostaniod receptors; an overview. J Lipid Mediat Cell Signal. 1995;12:343–359
  6. Gilmore NJ, Vane JR. Hormones released into the circulation when the urinary bladder of the anaesthetized dog is distended. Clin Sci. 1971;41:69–83
  7. Bultitude MI, Hills NH, Shuttleworth KE. Clinical and experimental studies on the action of prostaglandins and their synthesis inhibitors on detrusor muscle in vitro and in vivo. Br J Urol. 1976;48:631–637
  8. Kondo A, Kobayashi M, Takita T, Narita H. Effect of prostaglandin on urethral resistance and micturition. Urol Res. 1983;11:19–22
  9. Mutoh S, Ueda S, Yano S, Ikegami K, Sakanashi M. Effects of some prostaglandins on urinary bladder and urethra isolated form the dog. Urol Int. 1983;38:219–222
  10. Jeremy JY, Mikhailidis DP, Dandona P. The rat urinary bladder produced prostacyclin as well as other prostaglandins. Prostaglandins Leukot Med. 1984;16:235–248
  11. Jeremy JY, Tsang V, Mikhailidis DP, Rogers H, Morgan RJ, Dandona P. Eicosanoid synthesis by human urinary bladder mucosa – Pathological implications. Br J Urol. 1987;59:36–39
  12. Khalaf IM, Lehoux JG, Elshawarby LA, Elhilali MM. Release of prostaglandins into the pelvic venous blood of dogs in response to vesical distension and pelvic nerve stimulation. Invest Urol. 1979;17:244–247
  13. Eika B, Salling LN, Christensen LL, Andersen A, Laurberg S, Danielsen CC. Long-term observation of the detrusor smooth muscle in rats; its relationship to ovariectomy and estrogen treatment. Urol Res. 1990;18:439–442
  14. Parekh MH, Chichester P, Lobel RW, Aikawa K, Levin RM. Effects of castration on female rabbit bladder physiology and morphology. Urology. 2004;64:1048–1051
  15. Zhu Q, Ritchie J, Marouf N, Dion SB, Resnick NM, Elbadawi A, et al. Role of ovarian hormones in the pathogenesis of impaired detrusor contractility: evidence in ovariectomised rodents. J Urol. 2001;166:1136–1141
  16. Arnold S. Relationship of incontinence to neutering. In:  Kirk RW,  Bonagura JD editor. Kirk's Current Veterinary Therapy XI. Philadelphia: W.B. Saunders Company; 1992;p. 875–877
  17. Holt PE. Urinary incontinence in the bitch due to sphincter incompetence: prevalence in referred dogs and retrospective analysis of sixty cases. J Small Anim Pract. 1985;26:181–190
  18. Thrusfield M. Association between spaying and urinary incontinence in bitches. Vet Rec. 1985;116:695
  19. Holt PE. Urinary incontinence in the bitch. Vet Rec. 1990;127:604
  20. Reichler IM, Hubler M, JÖchle W, Trigg TE, Piché CA, Arnold S. The effect of GnRH analogs on urinary incontinence after ablation of the ovaries in dogs. Theriogenology. 2003;60:1207–1216
  21. Ponglowhapan S, Church DB, Khalid M. Differences in the expression of luteinizing hormone and follicle-stimulating hormone receptors in the lower urinary tract between intact and gonadectomised male and female dogs. Domest Anim Endocrinol. 2008;34:339–351
  22. Ponglowhapan S, Church DB, Scaramuzzi RJ, Khalid M. Luteinizing hormone and follicle-stimulating hormone receptors and their transcribed genes (mRNA) are present in the lower urinary tract of intact male and female dogs. Theriogenology. 2007;67:353–366
  23. Welle MM, Reichler IM, Barth A, Forster U, Sattler U, Arnold S. Immunohistochemical localization and quantitative assessment of GnRH-, FSH-, and LH-receptor mRNA Expression in canine skin: a powerful tool to study the pathogenesis of side effects after spaying. Histochem Cell Biol. 2006;126(5):527–535
  24. Ponglowhapan S, Church DB, Khalid M. Expression of cyclooxygenase-2 in the canine lower urinary tract with regard to the effects of gonadal status and gender. Theriogenology. 2009;71:1276–1288
  25. Ponglowhapan S, Church DB, Khalid M. Differences in the proportion of collagen and muscle in the canine lower urinary tract with regard to gonadal status and gender. Theriogenology. 2008;70:1516–1524
  26. Kershaw-Young CM, Khalid M, McGowan MR, Pitsillides AA, Scaramuzzi RJ. The mRNA expression of EP2 and EP4 and the changes in glycosaminoglycans in the sheep cervix at different stages of the oestrous cycle. Theriogenology. 2009;72:251–261
  27. Andersson KE, Forman A. Effects of prostaglandins on the smooth muscle of the urinary tract. Acta Pharmacol Toxicol (Copenh). 1978;43:90–95
  28. Ji H, Dailey TL, Long V, Chien EK. Prostaglandin E2 regulated cervical ripening: analysis of proteoglycan expression in the rat cervix. Am J Obstet Gynaecol. 2008;198:531–537
  29. Trabucco E, Soderberg M, Cobellis L, Torella M, Bystrom B, Ekman-Ordeberg G, et al. Role of proteoglycans in the organization of periurethral connective tissue in women with stress urinary incontinence. Maturitas. 2007;58:395–405
  30. Astle S, Thornton S, Slater DM. Identification and localization of prostaglandin E2 receptors in upper and lower segment human myometruim during pregnancy. Mol Hum Reprod. 2005;11:279–287
  31. Lintner F, Hertelendy F, Zsolnay B. Do steroid hormones influence the concentration of PGE2 alpha receptors of the uterine muscles?. Acta Chir Hung. 1989;30:109–117
  32. Jouanen A, Saintot M, Thaler-Dao H, Crastes de Paulet A. Prostaglandin synthesis from endogenous and exogenous arachidonic acid in the rat uterus: Effect of estradiol and progesterone. Prostaglandins leukot Med. 1985;18:321–336
  33. Mizrachi D, Shemesh M. Follicle-stimulating hormone receptor and its messenger ribonucleic acid are present in the bovine cervix and can regulate cervical prostanoid synthesis. Biol Reprod. 1999;61:776–784
  34. Shemesh M. Action of gonadotrophins on the uterus. Reproduction. 2001;121:835–842
  35. Dong YL, Yallampalli C. Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP2 and contractile FP receptors in the rat uterus. Biol Reprod. 2000;62:533–539
  36. Katsuyama M, Sugimoto Y, Morimoto K, Hasumoto K, Fukumoto M, Negishi M, et al. Distinct cellular localization of the messenger ribonucleic acid for prostaglandin E receptor subtypes in the mouse uterus during pseudopregnancy. Endocrinology. 1997;138:344–350
  37. Pavlakis AJ, Siroky MB, Leslie CA, Krane RJ. Prostaglandins in lower urinary tract. Neuro Urodyn. 1983;2:105–116
  38. Coit VA, Gibson IF, Evans NP, Dowell FJ. Neutering affects urinary bladder function by different mechanisms in male and female dogs. Eur J Pharmacol. 2008;584:153–158
  39. Reichler IM, Pfeiffer E, Piché CA, JÖchle W, Roos M, Hubler M, et al. Changes in plasma gonadotropin concentrations and urethral closure pressure in the bitch during the 12 months following ovariectomy. Theriogenology. 2004;62:1391–1402
  40. Salomon JF, Gouriou M, Dutot E, Borenstein N, Combrisson H. Experimental study of urodynamic changes after ovariectomy in 10 dogs. Vet Rec. 2006;159:807–811
  41. Borda E, Chaud M, Gutnisky R, Contreras Ortiz N, Gimeno MF, Gimeno AL. Relationships between prostaglandins and estrogens on the motility of isolated rings form the rat urinary bladder. J Urol. 1983;129:1250–1253
  42. Susset JG, Regnier CH. Viscoelastic properties of bladder strips: standardization of a technique. Invest Urol. 1981;18:445–450
  43. Lee T, Hedlund P, Newgreen D, Andersson KE. Urodynamic effects of a novel EP1 receptor antagonist in normal rats and rats with bladder outlet obstruction. J Urol. 2007;177:1562–1567
  44. Habib M, Krasnopolsky L, Gaafar S, Levin RM. Comparative studies on urethral function. World J Urol. 1996;14:388–392
  45. Celayir S, Kilic N, Soylet Y, Buyukunal C. Urodynamic findings in rabbit bladder. Pediatrik Cerrahi Dergisi. 1996;10:71–73
  46. Chun AL, Wein AJ, Harkaway R, Levin RM. Comparison of urinary bladder function in sexually mature and immature male and female rats. J Urol. 1990;143:1267–1271
  47. Longhurst PA, Eika B, Leggett RE, Levin RM. Comparison of urinary bladder function in 6 and 24 month male and female rats. J Urol. 1992;148:1615–1620
  48. Karanian JW, Moran FM, Ramey ER, Ramwell PW. Gender differences in prostaglandin receptors of rat aorta. Br J Pharmacol. 1981;72:10–12
  49. Nickel RF. Studies on the function of the urethra and bladder in continent and incontinent female dogs. PhD Thesis The Netherlands: Utrecht University; 1998;
  50. Nickel RF, van den Brom W. Simultaneous diuresis cysto-urethrometry and multi-channel urethral pressure profilometry in female dogs with refractory urinary incontinence. Am J Vet Res. 1997;58:691–696

PII: S0093-691X(10)00335-3

doi: 10.1016/j.theriogenology.2010.06.017

Theriogenology
Volume 74, Issue 8 , Pages 1450-1466 , November 2010

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