Theriogenology
Volume 74, Issue 3 , Pages 384-392 , August 2010

Stimulation of pulses of 13,14-dihydro-15-keto-PGF2α (PGFM) with estradiol-17β and changes in circulating progesterone concentrations within a PGFM pulse in heifers

  • O.J. Ginther

      Affiliations

    • Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    • Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 608 798 3777; fax: +1 608 798 4910
    • ,
  • H.K. Shrestha

      Affiliations

    • Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    • ,
  • M.J. Fuenzalida

      Affiliations

    • Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    • ,
  • S. Imam

      Affiliations

    • Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    • ,
  • M.A. Beg

      Affiliations

    • Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA

Received 19 January 2010 ,Revised 19 February 2010 ,Accepted 24 February 2010.

References 

  1. McCracken JA, Custer EE, Lamsa JC. Luteolysis: a neuroendocrine-mediated event. Physiol Rev. 1999;79:263–323
  2. Kindahl H, Edqvist LE, Granstrom E, Bane A. The release of prostaglandin F2 alpha as reflected by 15-keto-13,14-dihydroprostaglandin F2α in the peripheral circulation during normal luteolysis in heifers. Prostaglandins. 1976;11:871–878
  3. Mann GE, Lamming GE. Timing of prostaglandin F2α release episodes and oxytocin receptor development during luteolysis in the cow. Anim Reprod Sci. 2006;93:328–336
  4. Ginther OJ, Araujo RR, Palhao MP, Rodrigues BL, Beg MA. Necessity of sequential pulses of prostaglandin F2α for complete physiologic luteolysis in cattle. Biol Reprod. 2009;80:641–648
  5. Ginther OJ, Siddiqui MA, Beg MA. Physiologic and nonphysiologic effects of exogenous prostaglandin F2α on reproductive hormones in mares. Theriogenology. 2009;72:417–424
  6. Silvia WJ, Lewis GS, McCracken JA, Thatcher WW, Wilson LJ. Hormonal regulation of uterine secretion of prostaglandin F2 alpha during luteolysis in ruminants. Biol Reprod. 1991;45:655–663
  7. Harms PG, Malven PV. Effect of injected progesterone on estrus cycle length. J Dairy Sci. 1967;50:1006
  8. Ginther OJ. Effect of progesterone on length of estrus cycle in cattle. Am J Vet Res. 1970;31:493–496
  9. Woody CO, Ginther OJ, Pope AL. Effects of exogenous progesterone on corpora lutea induced in anestrus ewes. J Anim Sci. 1967;26:1113–1115
  10. Ginther OJ. Length of estrus cycle and size of corpus luteum in guinea pigs and sheep treated with progesterone at different days of the estrus cycle. Am J Vet Res. 1969;30:1975–1978
  11. Woody CO, Ginther OJ. Effect of exogenous progesterone on corpora luteum in unilaterally hysterectomized heifers. J Anim Sci. 1968;27:1387–1390
  12. Ginther OJ. Influence of exogenous progesterone and the uterus on ovarian activity in sheep. Endocrinology. 1968;83:613–615
  13. Ginther OJ. Utero-ovarian relationships in progesterone-treated guinea pigs. Am J Vet Res. 1969;30:261–267
  14. Louis TM, Parry DM, Robinson JS, Thorburn GD, Challis JR. Effects of exogenous progesterone and oestradiol on prostaglandin F and 13,14-dihydro-15-oxo prostaglandin F2alpha concentrations in uteri and plasma of ovariectomized ewes. J Endocrinology. 1977;73:427–439
  15. Vernon MW, Zavy MT, Asquith RL, Sharp DC. Prostaglandin F2alpha in the equine endometrium: steroid modulation and production capacities during the estrus cycle and early pregnancy. Biol Reprod. 1981;25:581–589
  16. Salfen BE, Cresswell JR, Xu ZZ, Bao B, Garverick HA. Effects of the presence of a dominant follicle and exogenous oestradiol on the duration of the luteal phase of the bovine oestrus cycle. J Reprod Fertil. 1999;115:15–21
  17. Araujo RR, Ginther OJ, Ferreira JC, Palhao MM, Beg MA, Wiltbank MC. Role of follicular estradiol-17beta in timing of luteolysis in heifers. Biol Reprod. 2009;81:426–437
  18. Ginther OJ. Length of the estrus cycle in sheep treated with estradiol. Am J Vet Res. 1970;31:973–975
  19. Karsch FJ, Noveroske JW, Roche JF, Norton HW, Nalbandov AV. Maintenance of ovine corpora lutea in the absence of ovarian follicles. Endocrinology. 1970;87:122–136
  20. Ginther OJ. Response of corpora lutea to cauterization of follicles in sheep. Am J Vet Res. 1971;32:59–62
  21. Fogwell RL, Cowley JL, Wortman JA, Ames NK, Ireland JJ. Luteal function in cows following destruction of ovarian follicles at midcycle. Theriogenology. 1985;23:389–398
  22. Ford SP, Weems CW, Pitts RE, Pexton JE, Butcher RL, Inskeep EK. Effects of estradiol-17β and progesterone on prostaglandins F in sheep uteri and uterine venous plasma. J Anim Sci. 1975;41:1407–1413
  23. Knickerbocker JJ, Thatcher WW, Foster DB, Wolfenson D, Bartol FF, Caton D. Uterine prostaglandin and blood flow responses to estradiol-17 beta in cyclic cattle. Prostaglandins. 1986;31:757–776
  24. Thatcher WW, Terqui M, Thimonier J, Mauleon P. Effect of estradiol-17 beta on peripheral plasma concentration of 15-keto-13,14-dihydro PGF2 alpha and luteolysis in cyclic cattle. Prostaglandins. 1986;31:745–756
  25. Al-Matubsi HY, Downing J, Jenkin G, Fairclough RJ. Effect of oestradiol on ovarian oxytocin secretion rate and luteolysis in the ewe after ovarian auto-transplantation. Reprod Fertil Dev. 1997;9:683–688
  26. Hixon JE, Hansel W. Evidence for preferential transfer of prostaglandin F2α to the ovarian artery following intrauterine administration in cattle. Biol Reprod. 1974;11:543–552
  27. Stellflug JN, Louis TM, Gorewit RC, Oxender WD, Hafs HD. Luteolysis induced by prostaglandin F2α before and after hysterectomy in heifers. Biol Reprod. 1977;17:535–540
  28. Baishya N, Cooper MJ, Hart IC, Jackson PS, Furr BJ, Jenkin G, et al. Effects of luteolytic doses of prostaglandin F2 alpha and cloprostenol on concentrations of progesterone, luteinizing hormone, follicle-stimulating hormone, glucose, insulin, growth hormone, thyroxine, prolactin and cortisol in jugular plasma of lactating dairy cows. Br Vet J. 1994;150:569–583
  29. Shrestha H, Beg MA, Imam S, Ginther OJ. Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2(alpha) in heifers. Reproduction. 2010;
  30. Shrestha HK, Beg MA, Siddiqui MA, Ginther OJ. Dynamic progesterone responses to simulation of a natural pulse of a metabolite of prostaglandin F2α in heifers. Anim Reprod Sci. 2009;
  31. Skarzynski DJ, Ferreira-Dias G, Okuda K. Regulation of luteal function and corpus luteum regression in cows: hormonal control, immune mechanisms and intercellular communication. Reprod in Dom Anim. 2008;43:Suppl 2:57–65
  32. Miyamoto A, Shirasuna K. Luteolysis in the cow: a novel concept of vasoactive molecules. Anim Reprod. 2009;6:47–59
  33. Miyamoto A, Shirasuna K, Sasahara K. Local regulation of corpus luteum development and regression in the cow: Impact of angiogenic and vasoactive factors. Dom Anim Endocrinol. 2009;37:159;–69
  34. Ginther OJ 1998 Ultrasonic Imaging and Animal Reproduction. Book 3. Cattle. Cross Plains, WI, USA: Equiservices Publishing.
  35. Ginther OJ, Bergfelt DR, Kulick LJ, Kot K. Selection of the dominant follicle in cattle: role of estradiol. Biol Reprod. 2000;63:383–389
  36. Kulick LJ, Kot K, Wiltbank MC, Ginther OJ. Follicular and hormonal dynamics during the first follicular wave in heifers. Theriogenology. 1999;52:913–921
  37. Ginther OJ, Silva LA, Araujo RR, Beg MA. Temporal associations among pulses of 13,14-dihydro-15-keto-PGF2alpha, luteal blood flow, and luteolysis in cattle. Biol Reprod. 2007;76:506–513
  38. Rouleau G, Babkine M, Dubreuil P. Factors influencing the development of jugular thrombophlebitis in cattle and comparison of 2 types of catheter. Can Vet J. 2003;44:399–404
  39. Fitzgerald BP, Affleck KJ, Barrows SP, Murdoch WL, Barker KB, Loy RG. Changes in LH pulse frequency and amplitude in intact mares during the transition into the breeding season. J Reprod Fertil. 1987;79:485–493
  40. Ginther OJ, Rodrigues BL, Ferreira JC, Araujo RR. Characterisation of pulses of 13,14-dihydro-15-keto-PGF2alpha (PGFM) and relationships between PGFM pulses and luteal blood flow before, during and after luteolysis in mares. Reprod Fertil Dev. 2008;20:684–693
  41. Siddiqui MAR, Gastal EL, Gastal MO, Almamum M, Beg MA, Ginther OJ. Relationship of vascualr perfusion of the wall of the preovualtory follicle to in vitro fertilisation and embryo development in heifers. Reproduction. 2009;137:689–697
  42. Kulick LJ, Bergfelt DR, Kot K, Ginther OJ. Follicle selection in cattle: follicle deviation and codominance within sequential waves. Biol Reprod. 2001;65:839–846
  43. Speroff L, Ramwell PW. Prostaglandin stimulation of in vitro progesterone synthesis. J Clin Endocrinol Metab. 1970;30:345–350
  44. Acosta TJ, Yoshizawa N, Ohtani M, Miyamoto A. Local changes in blood flow within the early and midcycle corpus luteum after prostaglandin F2α injection in the cow. Biol Reprod. 2002;66:651–658

PII: S0093-691X(10)00136-6

doi: 10.1016/j.theriogenology.2010.02.021

Theriogenology
Volume 74, Issue 3 , Pages 384-392 , August 2010

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