Theriogenology
Volume 73, Issue 9 , Pages 1202-1209 , June 2010

Short-term feed restriction decreases the systemic and intrafollicular concentrations of leptin and increases the vascularity of the preovulatory follicle in mares

  • M.O. Gastal

      Affiliations

    • Eutheria Foundation, Cross Plains, Wisconsin, USA
  • ,
  • E.L. Gastal

      Affiliations

    • Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, USA
    • Corresponding Author InformationCorresponding author. Tel.: +618 453 1774; fax: +618 453 5231.
    • Department of Animal Science, Food and Nutrition, Southern Illinois University Carbondale, 1205 Lincoln Drive, MC 4417, Carbondale, IL 62901, USA.
  • ,
  • M.A. Beg

      Affiliations

    • Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, USA
  • ,
  • O.J. Ginther

      Affiliations

    • Eutheria Foundation, Cross Plains, Wisconsin, USA
    • Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, USA

Received 1 October 2009 ,Revised 15 November 2009 ,Accepted 16 November 2009.

References 

  1. Diskin MG, Mackey DR, Roche JF, Sreenan JM. Effects of nutrition and metabolic status on circulating hormones and ovarian follicle development in cattle. Anim Reprod Sci. 2003;78:345–370
  2. Gentry LR, Thompson DL, Gentry GT, Davis KA, Godke RA, Cartmill JA. The relationship between body condition, leptin, and reproductive and hormonal characteristics of mares during the seasonal anovulatory period. J Anim Sci. 2002;80:2695–2703
  3. Henneke DR, Potter GD, Kreider JL. Body condition during pregnancy and lactation and reproductive efficiency of mares. Theriogenology. 1984;21:897–909
  4. Kubiak JR, Crawford BH, Squires EL, Wrigley RH, Ward GM. The influence of energy intake and percentage of body fat on the reproductive performance of nonpregnant mares. Theriogenology. 1987;28:587–598
  5. Gentry LR, Thompson DL, Gentry GT, Davis KA, Godke RA. High versus low body condition in mares: interactions with responses to somatotropin, GnRH analog, and dexamethasone. J Anim Sci. 2002;80:3277–3285
  6. Gastal MO, Gastal EL, Spinelli V, Ginther OJ. Relationships between body condition and follicle development in mares. Anim Reprod. 2004;1:115–121
  7. McManus CJ, Fitzgerald BP. Effects of a single day of feed restriction on changes in serum leptin, gonadotropins, prolactin, and metabolites in aged and young mares. Domest Anim Endocrinol. 2000;19:1–13
  8. Murphy MG, Enright WJ, Crowe MA, McConnell K, Spicer LJ, Boland MP, et al. Effect of dietary intake on pattern of growth of dominant follicles during the oestrous cycle in beef heifers. J Reprod Fertil. 1991;92:333–338
  9. Bossis I, Wettemann RP, Welty SD, Vizcarra JA, Spicer LJ, Diskin MG. Nutritionally induced anovulation in beef heifers: ovarian and endocrine function preceding cessation of ovulation. J Anim Sci. 1999;77:1536–1546
  10. Mackey DR, Sreenan JM, Roche JF, Diskin MG. Effect of acute nutritional restriction on incidence of anovulation and periovulatory estradiol and gonadotropin concentrations in beef heifers. Biol Reprod. 1999;61:1601–1607
  11. Comin A, Gerin D, Cappa A, Marchi V, Renaville R, Motta M, et al. The effect of an acute energy deficit on the hormone profile of dominant follicles in dairy cows. Theriogenology. 2002;58:899–910
  12. Rhodes FM, Entwistle KW, Kinder JE. Changes in ovarian function and gonadotropin secretion preceding the onset of nutritionally induced anestrus in Bos indicus heifers. Biol Reprod. 1996;55:1437–1443
  13. Miller DW, Blache D, Boukhliq R, Curlewis JD, Martin GB. Central metabolic messengers and the effects of nutrition on gonadotrophin secretion in sheep. J Reprod Fertil. 1998;112:347–356
  14. Tokach MD, Pettigrew JE, Dial GD, Wheaton JE, Crooker BA, Johnston LJ. Characterization of luteinizing hormone secretion in the primiparous, lactating sow: relationship to blood metabolites and return-to-estrus interval. J Anim Sci. 1992;70:2195–2201
  15. Silva LA, Gastal EL, Gastal MO, Beg MA, Ginther OJ. Relationship between vascularity of the preovulatory follicle and establishment of pregnancy in mares. Anim Reprod. 2006;3:339–346
  16. Siddiqui MA, Almamun M, Ginther OJ. Blood flow in the wall of the preovulatory follicle and its relationship to pregnancy establishment in heifers. Anim Reprod Sci. 2009;113:287–292
  17. Bhal PS, Pugh N, Chui D, Gregory L, Walker SM, Shaw RW. The use of transvaginal power Doppler ultrasonography to evaluate the relationship between perifollicular vascularity and outcome in in-vitro fertilization treatment cycles. Hum Reprod. 1999;14:939–945
  18. Clarke IJ, Henry BA. Leptin and reproduction. Rev Reprod. 1999;44:48–55
  19. Williams GL, Amstalden M, Garcia MR, Stanko RL, Nizielski SE, Morrison CD, et al. Leptin and its role in the central regulation of reproduction in cattle. Domest Anim Endocrinol. 2002;23:339–349
  20. Prolo P, Wong ML, Licinio J. Leptin. Int J Biochem Cell Biol. 1998;30:1285–1290
  21. Chilliard Y, Ferlay A, Faulconnier Y, Bonnet M, Rouel J, Bocquier F. Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants. Proc Nutr Soc. 2000;59:127–134
  22. Fitzgerald BP, McManus CJ. Photoperiodic versus metabolic signals as determinants of seasonal anestrus in the mare. Biol Reprod. 2000;63:335–340
  23. Buff PR, Dodds AC, Morrison CD, Whitley NC, McFadin EL, Daniel JA, et al. Leptin in horses: tissue localization and relationship between peripheral concentrations of leptin and body condition. J Anim Sci. 2002;80:2942–2948
  24. Henneke DR, Potter GD, Kreider JL, Yeats BF. Relationship between body condition score, physical measurements and body fat percentage in mares. Equine Vet J. 1983;15:371–372
  25. Colbern GT, Reagan WJ. Ovariectomy by colpotomy in mares. Comp Cont Edu Pract Vet. 1987;9:1035–1038
  26. Gastal EL, Gastal MO, Ginther OJ. The suitability of echotexture characteristics of the follicular wall for identifying the optimal breeding day in mares. Theriogenology. 1998;50:1025–1038
  27. Gastal EL, Gastal MO, Ginther OJ. Relationships of changes in B-mode echotexture and colour-Doppler signals in the wall of the preovulatory follicle to changes in systemic oestradiol concentrations and the effects of human chorionic gonadotrophin in mares. Reproduction. 2006;131:699–709
  28. Donadeu FX, Ginther OJ. Follicular waves and circulating concentrations of gonadotrophins, inhibin and oestradiol during the anovulatory season in mares. Reproduction. 2002;124:875–885
  29. Gastal EL, Bergfelt DR, Nogueira GP, Gastal MO, Ginther OJ. Role of luteinizing hormone in follicle deviation based on manipulating progesterone concentrations in mares. Biol Reprod. 1999;61:1492–1498
  30. Ginther OJ, Gastal EL, Gastal MO, Checura CM, Beg MA. Dose-response study of intrafollicular injection of insulin-like growth factor-I on follicular fluid factors and follicle dominance in mares. Biol Reprod. 2004;70:1063–1069
  31. Zar JH. Biostatistical Analysis. 2nd edition. Prentice-Hall; 1984;
  32. Butzow TL, Moilanen JM, Lehtovirta M, Tuomi T, Hovatta O, Siegberg R, et al. Serum and follicular fluid leptin during in vitro fertilization: relationship among leptin increase, body fat mass, and reduced ovarian response. J Clin Endocrinol Metab. 1999;84:3135–3139
  33. Wu MH, Tsai SJ, Pan HA, Hsiao KY, Chang FM. Three-dimensional power Doppler imaging of ovarian stromal blood flow in women with endometriosis undergoing in vitro fertilization. Ultrasound Obstet Gynecol. 2003;21:480–485
  34. Govoni N, Galeati G, Castellani G, Tamanini C. Leptin concentrations in plasma and follicular fluid from prepubertal gilts as influenced by fasting, refeeding and insulin. Horm Metab Res. 2005;37:152–158
  35. Ahima RS, Prabakaran D, Mantzoro C, Qu D, Lowell B, Maratos-Flier E, et al. Role of leptin in the neuroendocrine response to fasting. Nature. 1996;382:250–252
  36. Houseknecht KL, Baile CA, Matteri RL, Spurlock ME. The biology of leptin: a review. J Anim Sci. 1998;46:1405–1420
  37. Pineda MH. Female reproductive system. In:  Pineda MH,  Dooley MP editor. McDonald's Veterinary Endocrinology and Reproduction. 5th edition. Iowa State Press; 2003;p. 328

PII: S0093-691X(10)00020-8

doi: 10.1016/j.theriogenology.2009.11.032

Theriogenology
Volume 73, Issue 9 , Pages 1202-1209 , June 2010