Theriogenology
Volume 74, Issue 8 , Pages 1321-1326 , November 2010

Phosphodiesterase inhibitor 3-isobutyl-methyl-xanthine stimulates reproduction in rabbit females

  • A.V. Sirotkin

      Affiliations

    • Institute of Genetics and Animal Reproduction, Animal Production Research Centre Nitra, Lužianky near Nitra, Slovak Republic
    • Department of Zoology and Anthropology, Constantine the Philosopher University, Nitra, Slovak Republic
    • Corresponding Author InformationCorresponding author. Tel.: +421 37 6546335; fax: +421 37 6546480.
    • ,
  • S. Chadio

      Affiliations

    • Department of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece
    • ,
  • P. Chrenek

      Affiliations

    • Institute of Genetics and Animal Reproduction, Animal Production Research Centre Nitra, Lužianky near Nitra, Slovak Republic
    • Department of Biochemistry and Biotechnology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Nitra, Slovak Republic
    • ,
  • E. Xylouri

      Affiliations

    • Department of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece
    • ,
  • H. Fotopouloy

      Affiliations

    • Department of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece

Received 26 June 2009 ,Revised 9 September 2009 ,Accepted 9 September 2009.

References 

  1. Makarevich AV, Sirotkin AV. Presumptive mediators of growth hormone action on insulin-like growth factor I release by porcine ovarian granulosa cells. Biol. Signals Recept. 2000;9:248–254
  2. Conti M. Specificity of the cyclic adenosine 3′,5′-monophosphate signal in granulosa cell function. Biol. Reprod. 2002;67:1653–1661
  3. Mehlmann LM. Stops and starts in mammalian oocytes: recent advances in understanding the regulation of meiotic arrest and oocyte maturation. Reproduction. 2005;130:791–799
  4. Masciarelli S, Horner K, Liu C, Park SH, Hinckley M, Hockman S, et al. Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. J. Clin. Invest. 2004;114:196–205
  5. Sirotkin AV. Control of reproductive processes by growth hormone: extra- and intracellular mechanisms. Vet. J. 2005;170:307–317
  6. Sirotkin AV, Makarevich AV, Gennieser HG, Kotwica J, Hetenyi L. Effect of four cGMP analogues with different mechanisms of action on hormone release by porcine ovarian granulosa cells in vitro. Exp. Clin. Endocrinol. Diabetes. 2000;108:214–219
  7. LaPolt PS, Leung K, Ishimaru R, Tafoya MA, You-Hsin CHJ. Roles of cyclic GMP in modulating ovarian functions. Reprod. Biomed. Online. 2003;6:15–23
  8. Makarevich AV, Sirotkin AV. The involvement of the GH/IGF-I axis in the regulation of secretory activity by bovine oviduct epithelial cells. Anim. Reprod. Sci. 1997;48:197–207
  9. Orihuela PA, Parada-Bustamante A, Cortés PP, Gatica C, Croxatto HB. Estrogen receptor, cyclic adenosine monophosphate, and protein kinase A are involved in the nongenomic pathway by which estradiol accelerates oviductal oocyte transport in cyclic rats. Biol. Reprod. 2003;68:1225–1231
  10. Wang Z, Shi F, Jiang YQ, Lu LZ, Wang H, Watanabe G, et al. Changes of cyclic AMP levels and phosphodiesterase activities in the rat ovary. J. Reprod. Dev. 2007;53:717–725
  11. Park JY, Richard F, Chun SY, Park JH, Law E, Horner K, et al. Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle. Mol. Endocrinol. 2003;17:1117–1130
  12. McKenna SD, Pietropaolo M, Tos EG, Clark A, Fischer D, Kagan D, et al. Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats. Endocrinology. 2005;146:208–214
  13. Sirotkin AV, Chrenek P, Chadio S, Xylouri E, Fotopouloy H, Makarevich AV. Phosphodiesterase inhibitor 3-isobutyl-methyl-xanthine affects rabbit ovaries and oviduct. Eur J Pharmacol. 2010;643:145–151
  14. Chrenek P, Petrovičová I, Rafay J, Bulla J. Superovulation and recovery of zygotes suitable for double-microinjection in three rabbit populations. Czech J. Anim. Sci. 1999;44:471–474

PII: S0093-691X(09)00416-6

doi: 10.1016/j.theriogenology.2009.09.013

Theriogenology
Volume 74, Issue 8 , Pages 1321-1326 , November 2010

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