Theriogenology
Volume 72, Issue 9 , Pages 1195-1201 , December 2009

Effect of oxytocin and flunixin meglumine on uterine response to insemination in mares

  • A.M. Risco

      Affiliations

    • Service of Research and Technological Development, Junta de Extremadura, Estate “La Orden,” Guadajira (Ba), Spain
    • ,
  • T. Reilas

      Affiliations

    • MTT Agrifood Research Finland, Animal Production Research, Equines, Ypäjä, Finland
    • ,
  • L. Muilu

      Affiliations

    • University of Helsinki, Department of Production Animal Medicine, Saarentaus, Finland
    • ,
  • M. Kareskoski

      Affiliations

    • University of Helsinki, Department of Production Animal Medicine, Saarentaus, Finland
    • ,
  • T. Katila

      Affiliations

    • University of Helsinki, Department of Production Animal Medicine, Saarentaus, Finland
    • Corresponding Author InformationCorresponding author. Tel.: +358 40 5142956; fax: +358 19 6851181.

Received 16 April 2009 ,Revised 26 June 2009 ,Accepted 3 July 2009.

References 

  1. Kotilainen T, Huhtinen M, Katila T. Sperm-induced leukocytosis in the equine uterus. Theriogenology. 1994;41:629–636
  2. Troedsson MHT. Uterine clearance and resistance to persistent endometritis in the mare. Theriogenology. 1999;52:461–471
  3. Henry M, Vandeplassche G, Coryn M, Spincemaille J, Vandeplassche M. Excessive edema of genital tract in the mare. Zbl Vet Med A. 1981;28:390–409
  4. Ginther OJ. Reproductive Biology of the Mare. Basic and Applied Aspects. 2nd Edition. Equiservices; 1992;
  5. Reilas T, Katila T, Mäkelä O, Huhtinen M, Koskinen E. Intrauterine fluid accumulation in estrous mares. Acta Vet Scand. 1997;38:69–78
  6. Tunon A-M, Ekwall H, Nummijärvi A, Rodriquez-Martinez H. X-ray microanalysis of the secretory epithelium of the endometrial glands and intraluminal uterine fluid in estrous mares. Reprod Domest Anim. 2000;35:221–227
  7. Squires EL, Barnes CK, Rowley HS, McKinnon AO, Pickett BW, Shideler RK. Effect of uterine fluid and volume of extender on fertility. In: Proc. 35th Ann Conv Am Assoc Equine Practitioners, 1989, pp. 25–30.
  8. McKinnon AO, Squires EL, Carnevale EM, Harrison LA, Frantz DD, McChesney AE, et al. Diagnostic ultrasonography of uterine pathology in the mare. Proc Am Assoc Equine Practitioners. 1987;33:605–622
  9. Troedsson MHT. Therapeutic considerations for mating-induced endometritis. Pferdeheilkunde. 1997;13:516–520
  10. Zent WW, Troedsson MHT, Xue JL. Post breeding uterine fluid accumulation in a normal population of Thoroughbred mares: a field study. Proc Am Assoc Equine Practitioners. 1998;44:64–65
  11. Brinsko SP, Rigby SL, Varner DD, Blanchard TL. A practical method for recognizing mares susceptible to post breeding endometritis. Presented at: 49th AAEP 2003, New Orleans. Available at: www.ivis.org/proceedings/AAEP/2003/brinsko2/chapter_frm.asp?LA=1. 21.11.2003.
  12. LeBlanc MM, Johnson RD, Calderwood Mays MB, Valderrama C. Lymphatic clearance of India ink in reproductively normal mares and mares susceptible to endometritis. Biol Reprod Mono. 1995;1:501–506
  13. Evans MJ, Hammer JM, Gason LM, Graham CS, Asbury AC, Irvine CHG. Clearance of bacteria and non antigenic markers following intrauterine inoculation into maiden mares: effect of steroid hormone environment. Theriogenology. 1986;26:37–50
  14. Allen WE. Investigation into the use of exogenous oxytocin for promoting uterine drainage in mares susceptible to endometritis. Vet Rec. 1991;128:593–594
  15. Pycock JF. Cervical function and uterine fluid accumulation in mares. Proc JP Hughes Int Workshop on Equine Endometritis. Reviewed by WR Allen. Equine Vet J 1993; 25:191.
  16. LeBlanc M, Neuwirth L, Mauragis D, Klapstein E, Tran T. Oxytocin enhances clearance of radiocolloid from the uterine lumen of reproductively normal mares and mares susceptible to endometritis. Equine Vet J. 1994;26:279–282
  17. Troedsson MHT, Liu IKL, Ing M, Pascoe J, Thurmond M. Multiple site electromyography recordings of uterine activity following an intrauterine bacterial challenge in mares susceptible and resistant to chronic uterine infections. J Reprod Fert. 1993;99:307–313
  18. Rigby SL, Barhoumi R, Burghardt RC, Colleran P, Thompson JA, Varner DD, et al. Mares with delayed uterine clearance have an intrinsic defect in myometrial function. Biol Reprod. 2001;65:740–747
  19. LeBlanc MM. Oxytocin—the new wonder drug for treatment of endometritis?. Equine Vet Educ. 1994;6:39–43
  20. Troedsson MH, Liu IK, Ing M, Pascoe J. Smooth muscle electrical activity in the oviduct, and the effect of oxytocin, prostaglandin F2α, and prostaglandin E2 on the myometrium and the oviduct of the cycling mare. Biol Reprod Mono. 1995;1:475–478
  21. Cadario ME, Merrit AM, Archbald LF, Thatcher WW, LeBlanc MM. Changes in intrauterine pressure after oxytocin administration in reproductively normal mares and in those with a delay in uterine clearance. Theriogenology. 1999;51:1017–1025
  22. Cadario ME, Thatcher WW, Klapstein E, Merrit AM, Archbald LF, Thatcher MJ, et al. Dynamics of prostaglandin secretion, intrauterine fluid and uterine clearance in reproductively normal mares and mares with delayed uterine clearance. Theriogenology. 1999;52:1181–1192
  23. Pycock JF, Newcombe JR. Assessment of the effect of three treatments to remove intrauterine fluid on pregnancy rate in the mare. Vet Rec. 1996;138:320–323
  24. Knutti B, Pycock JF, van der Wejden GC, Küpfer U. The influence of early postbreeding uterine lavage on pregnancy rate in mares with intrauterine fluid accumulations after breeding. Equine Vet Educ. 2000;12:267–270
  25. Rasch K, Schoon HA, Sieme H, Klug E. Histomorphological endometrial status and influence of oxytocin on the uterine drainage and pregnancy rate in mares. Equine Vet J. 1996;28:455–460
  26. Jain TL, Saade GR, Garfield Re. Uterine contraction. In: Knobil E, Neill JD (Eds.), Encyclopedia of Reproduction, Volume 4. Academic Press, 1999, pp. 932–942.
  27. LeBlanc MM. Effects of oxytocin, prostaglandin and phenylbutazone on uterine clearance of radiocolloid. Pferdeheilkunde. 1997;13:483–485
  28. Cadario ME, Thatcher MJD, LeBlanc MM. Relationship between prostaglandin and uterine clearance of radiocolloid in the mare. Biol Reprod. 1995;1:495–500
  29. Kenney RM, Bergman RV, Cooper WL, Morse GW.;1; Minimal contamination techniques for breeding mares: technique and preliminary findings. In: Proc 21st Ann Conv Am Assoc Equine Pract, 1975, pp. 289–292.
  30. Paccamonti DL, Pycock JF, Taverne MAM, Bevers M, van der Wejden GC, Gutjahr S, et al. PGFM response to exogenous oxytocin and determination of the half-life of oxytocin in nonpregnant mares. Equine Vet J. 1999;31:285–288
  31. Available at: Veterinary Edition Drugs.com. Flunixin meglumine injection. http://www.drugs.com/vet/flunixin-meglumine-injection.html (22.7.2009).
  32. Sinnemaa L, Järvimaa T, Lehmonen N, Mäkelä O, Reilas T, Sankari S, et al. Effect of insemination volume on uterine contractions and inflammatory response and on elimination of semen in the mare uterus – scintigraphic and ultrasonographic studies. J Vet Med A. 2005;52:466–471
  33. Kenney RM. Cyclic and pathologic changes of the mare endometrium as detected by biopsy, with a note on early embryonic death. J Am Vet Med Assoc. 1978;172:241–262
  34. Reilas T, Ristiniemi M, Katila T. Influence of hormone replacement therapy and bacterial inoculation on proteins and enzymes in uterine lavage fluid of ovariectomized mares. Reprod Domest Anim. 1998;33:11–19
  35. Kenney RM, Doig PA. Equine endometrial biopsy. In:  Morrow DA editors. Current Therapy in Theriogenology. WB Saunders; 1986;p. 723–729
  36. SPSS for Windows, Rel. 11.0.1 2001. Chicago: SPSS Inc.
  37. Pycock JF. How to maximize the chances of breeding successfully from the older maiden mare. Presented at 52th AAEP 2006; 52:245–249. Available at: www.ivis.org/proceedings/aaep/2006/pycock/chapter.asp?LA=1. 6.12.2006.
  38. Campbell MLH, England GCW. A comparison of the ecbolic efficacy of intravenous and intrauterine oxytocin treatments. Theriogenology. 2002;58:473–477
  39. Gutjahr S, Paccamonti DL, Pycock JF, Taverne MAM, Dieleman SJ, van der Wejden GC. Effect of dose and day of treatment on uterine response to oxytocin in mares. Theriogenology. 2000;54:447–456
  40. Bliss A, Campbell M. Evaluation of the efficacy of two different doses of oxytocin on uterine fluid clearance in mares. In: Proceedings of the European Equine Meeting of the Year 2008 – XIV SIVE – FEEVA Congress, Venice, Italy, 2008. Available at: www.ivis.org/proceedings/sive/2008/pdf/81.pdf. 27.1.2008.
  41. Nikolakopoulos E, Watson ED. Uterine contractility is necessary for the clearance of intrauterine fluid but not bacteria after bacterial infusion in the mare. Theriogenology. 1999;52:413–423
  42. Kolm G, Gemeiner M, Deichsel K, Budik S, Aurich J, Aurich C. Effect of clenbuterol on the clearance of particles of charcoal (4 to 90μm) from the uteri of mares. Vet Rec. 2005;156:279–281
  43. Semrad SD, Hardee GE, Hardee MM, Moore JN. Flunixin meglumine given in small doses: pharmacokinetics and prostaglandin inhibition in healthy horses. Am J Vet Res. 1985;46:2474–2479

PII: S0093-691X(09)00357-4

doi: 10.1016/j.theriogenology.2009.07.012

Theriogenology
Volume 72, Issue 9 , Pages 1195-1201 , December 2009

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