Theriogenology
Volume 61, Issue 6 , Pages 1171-1179 , 15 April 2004

Reversibility of the reproductive toxicity of gossypol in peripubertal bulls

  • Magdy E Hassan

      Affiliations

    • Department of Veterinary Clinical Medicine, University of Illinois, Urbana-Champaign, IL, USA
    • ,
  • Geof W Smith

      Affiliations

    • Department of Population Health and Pathobiology, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-919-513-6288; fax: +1-919-513-6464.
    • ,
  • Randall S Ott

      Affiliations

    • Department of Veterinary Clinical Medicine, University of Illinois, Urbana-Champaign, IL, USA
    • ,
  • Daniel B Faulkner

      Affiliations

    • Department of Veterinary Biosciences and Animal Sciences, University of Illinois, Urbana-Champaign, IL, USA
    • ,
  • Lawrence D Firkins

      Affiliations

    • Department of Pathobiology, University of Illinois, Urbana-Champaign, IL, USA
    • ,
  • E.J Ehrhart

      Affiliations

    • Laboratories of Veterinary Diagnostic Medicine, University of Illinois, Urbana-Champaign, IL, USA
    • ,
  • David J Schaeffer

      Affiliations

    • Department of Veterinary Biosciences, University of Illinois, Urbana-Champaign, IL, USA

Received 10 April 2003 ,Accepted 4 July 2003.

References 

  1. Randel RD, Chase CC, Wyse SJ. Effect of gossypol and cottonseed products on reproduction of mammals. J. Anim. Sci. 1992;70:1628–1638
  2. Chenoweth PJ, Risco CA, Larsen RE, Velez J, Tran T, Chase CC. Effect of dietary gossypol on aspects of semen quality, sperm morphology and sperm production in young Brahman bulls. Theriogenology. 1994;2:1–13
  3. Chase CC, Bastidas P, Ruttle JL, Long CR, Randel RD. Growth and reproductive development in Brahman bulls fed diets containing gossypol. J. Anim. Sci. 1994;72:445–452
  4. Arshami J, Ruttle JL. Effects of diets containing gossypol on spermatogenic tissues of young bulls. Theriogenology. 1988;30:507–516
  5. Hoffer AP, Lisser SP. Recovery of normal testicular ultrastructure and sperm motility after cessation of gossypol treatment in rats. J. Androl. 1984;5:416–423
  6. Hancock JL. The morphology of boar spermatozoa. J. R. Micro. Soc. 1957;76:84–97
  7. Ott RS. Breeding soundness examination of bulls. In: Morrow DA, editor. Current Therapy in Theriogenology, 2nd ed. Philadelphia: WB Saunders; 1986. p. 125–36.
  8. Lagerlof N. The history of cytological and histological examination of sperm and testes. Communication of Veterinary College of State University of Ghent; 1966.
  9. Barth AD, Oko RJ. Abnormal morphology of bovine spermatozoa. Ames: Iowa State University Press; 1989.
  10. Veeramachaneni DNR, Ott RS, Heath EM, McEntee K, Bolt DJ, Hixon JE. Pathophysiology of small testes in beef bulls: relationship between scrotal circumference, histopathologic features of testes and epididymides, seminal characteristics, and endocrine profiles. Am. J. Vet. Res. 1986;47:1988–1999
  11. Velasquez-Pereira J, Chenoweth PJ, McDowell LR, Risco CA, Staples CA, Prichard D, et al.  Reproductive effects of feeding gossypol and vitamin E to bulls. J. Anim. Sci. 1998;76:2894–2904
  12. Cusack PMV, Perry V. The effect of feeding whole cottonseed on fertility of bulls. Aust. Vet. J. 1995;72:463–470
  13. Abdel-Raouf M. Sexual behavior and semen picture of bulls of the Swedish Red and White breed between the ages of 9 and 15 months. Nord. Vet. Med. 1965;17:318–322
  14. Johnson KR, Dewey CE, Bobo JK, Kelling CL, Lunstra DD. Prevalence of morphologic defects in spermatozoa from beef bulls. J. Am. Vet. Med. Assoc. 1998;213:1468–1471
  15. Madrid N, Ott RS, Veeramachaneni RDN, Parrett DF, Vanderwert W, Willms CL. Scrotal circumference, seminal characteristics, and testicular lesions of yearling Angus bulls. Am. J. Vet. Res. 1988;49:579–585
  16. Jimenez DA, Chandler JE, Adkinson RW, Nipper WA, Baham A, Saxton AM. Effect of feeding gossypol in cottonseed meal on growth, semen quality, and spermatogenesis of yearling Holstein bulls. J. Dairy Sci. 1989;72:866–1875
  17. Calhoun MC, Kuhlmann SW, Baldwin Jr BC. Assessing the gossypol status of cattle fed cotton feed products. Proc Pacific Northwest Anim Nutr Conf 1995:1–12.
  18. Waller DP, Bunyapraphatsara N, Martin A, Vournazos CJ, Ahmed MS, Soejarto DD, et al.  Effect of (+)-gossypol on fertility in male hamsters. J. Androl. 1983;4:276–279
  19. Hoffer AP, Agarwal A, Meltzer P, Herlihy P, Naqvi RH, Lindberg MC, et al.  Ultrastructural, fertility, and spermicidal studies with isomers and derivatives of gossypol in male hamsters. Biol. Reprod. 1987;37:909–924
  20. Rogers GM, Poore MH. Optimal feeding management of gossypol-containing diets for beef cattle. Vet. Med. 1995;90:995–1002
  21. Smally SA, Bicknell EJ. Gossypol toxicity in dairy cattle. Comp. Contin. Educ. Pract. Vet. 1982;4:378–381

PII: S0093-691X(03)00302-9

doi: 10.1016/j.theriogenology.2003.07.007

Theriogenology
Volume 61, Issue 6 , Pages 1171-1179 , 15 April 2004

Article Tools